Brain-behavior relationships in Cognitively Healthy and Mild Cognitively

 
   Lead Investigator:    Ariana Stickel
   Institution      :    The University of Arizona
   E-Mail           :    astickel@email.arizona.edu
   Proposal ID      :    720


   Publications:


1  Stickel A, McKinnon A, Ryan L
   Memory and processing speed predict functional independence differentially in non-Hispanic and Hispanic White middle aged and older adults
   2018   Abstract  Arizona Alzheimer's Consortium , 

   ACCEPTED



2  Stickel A, Ryan L
   Associations between cardiovascular risk factors and cognition in late middle age and older Hispanics compared to non-Hispanic Whites
   2017   Abstract  Arizona Alzheimer's Consortium , 

   ACCEPTED





   Proposal Description:
   Our goal is to characterize patterns of brain-behavior relationships in           cognitively healthy and mild cognitively impaired Hispanics compared to           non-Hispanic Whites. Structural brain measures (i.e., gray matter volumes,        white matter integrity, and white matter hyperintensities) will be used to        predict memory and executive functioning in Hispanics and non-Hispanic Whites.    Ethnic groups will be matched as best as possible on age, vocabulary, gender,     and APOE e4 status. A secondary aim of this project is to investigate whether     cardiovascular related measures, like blood pressure, help explain                brain-behavior relationships and whether they do so to the same degree in         Hispanics as in non-Hispanic Whites. We are particularly interested in this       understudied area because Hispanics tend to live longer than non-Hispanic         whites in the presence of cardiovascular diseases, despite having greater         incidence of cardiovascular risk factors, yet it is unclear how such patterns     relate to brain structure and cognition.